ANYL 261 |
| Mass spectrometry has been used to analyze small organic acids that are biochemically and clinically significant for decades. The utility of this analytical instrument for measuring multiple compounds in a complex mixture with chromatography for clinical chemistry was demonstrated in this application. However, these methods were somewhat tedious and required a considerable degree of expertise in the interpretation of the data produced by such a system. More recently, this multiple profile concept has re-emerged with the application of tandem MS to the analysis of amino acids and acylcarnitines in a dried blood spot. The analysis is robust, reproducible and is currently being used in dozens of laboratories throughout the world. In keeping with the concept of multiple metabolite or profile analysis, the utilization of mass spectrometry will continue to expand throughout the clinical community. Challenges still lie ahead in the application of proteomics in clinical chemistry but we are in the midst of success of the technology in metabolomics. |
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Disease Diagnostics
8:30 AM-10:55 AM, Monday, 27 March 2006 Georgia World Congress Center -- B214, Oral
Division of Analytical Chemistry |