I&EC 306 |
| In the article, Armstrong, D.W.; Zhang, L.-K.; He, L.; Gross, M.L."Ionic liquids as matrixes for matrix-assisted laser desorption/ionization mass spectrometry" Anal.Chem.(2001),73,3679,we introduced the use of ionic liquids for MALDI and described their advantages relative to solid matrices. The most notable advantage is the consistency of producing spectra from one laser spot to another, which is quite unlike the outcome with traditional solid matrices where a "sweet spot" must be sought for good performance. Furthermore, quantification can be achieved over a larger concentration dynamic range than with solid matrices. The slope of the calibration curve may be predictable knowing the hydrophobicity and the molecular weight of the polypeptide. These advantages may have an impact on analytical proteomics. An area where MALDI has had sparse impact, however, is in the analysis of complex phospholipids. Here the use of ionic liquids leads to considerable improvements in MALDI performance compared to that obtained with solid matrices. These topics will be sujects of the lecture. |
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Ionic Liquids: Not Just Solvents Anymore OR Ionic Liquids: Parallel Futures (Sponsored by Green Chemistry and Engineering, Separation Science and Technology and Novel Chemistry with Industrial Applications Sub-Divisions)
8:15 AM-12:30 PM, Thursday, 30 March 2006 Georgia World Congress Center -- B314, Oral
Division of Industrial and Engineering Chemistry |