Green reaction media for the Passerini reaction

I&EC 125

Carlos Kleber Zago Andrade, ckleber@unb.br, Sayuri Cristina Santos Takada, Paulo Anselmo Ziani Suarez, and Valério Cassiano Soares. Instituto de Química, Universidade de Brasília, Campus Universitário, Asa Norte, C.P. 4478, Brasília, DF, 70910-970, Brazil
α-Acyloxycarboxamides were easily assessed in one step by the multicomponent reaction between carboxylic acids, aldehydes and C-isocyanides (Passerini reaction) using ionic liquids or poliethyleneglicol (PEG 400) as green reaction media. The reactions went to completion in short reaction times and the products were obtained in most cases in excelent yields under very mild conditions. The results obtained herein were better in comparison to the same reactions performed in organic solvents. Either the ionic liquids or PEG were recovered and reused for at least five consecutive runs without significant change in the yields or purity.