ANYL 82 |
| Hadamard Time-of-flight Mass Spectrometry (HT-TOFMS) is a technique that attempts to increase the duty cycle of time-of-flight measurements by introducing multiple ion packets per scan in the mass spectrometer. The ion packets are created by pseudorandom modulation achieved by deflection of a continuous beam of electrosprayed ions using a Bradbury-Nielson Gate (BNG). Resolution in previous implementations of our techniques depends on the time base of the modulation waveform that is the clock frequency of the PLD. Here we present our first explorations of a new on-axis spectrometer designed around an imaging detector and a commercial ion source. We describe the dependence of the resolution on various instrumental parameters and the shape of different waveforms and the insight gained when imaging the fast deflection process. Ways of improving the resolution of the experiment are suggested based on the experimental data obtained and the advantages of using a imaging detector are discussed. |
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General Session
7:00 PM-9:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster
Sci-Mix
Division of Analytical Chemistry |