Investigation of vancomycin dimers as chiral selectors via capillary electrophoresis

ANYL 240

Timothy J. Ward, wardtj@millsaps.edu and Jason P. Eastlack. Department of Chemistry, Millsaps College, Box 150306, 1701 North State Street, Jackson, MS 39210
The macrocyclic antibiotics are a powerful class of chiral selectors for CE that have significantly extended the scope of chiral separations. The macrocyclic antibiotics contain the types of functional groups and spatial arrangement that provide multiple enantioselective interactions for chiral recognition. Previously vancomycin monomer has been used to separate numerous chiral compounds. In this work, vancomycin dimers attached via covalent bonding, were used to separate chiral solutes. The physico-chemical properties and behavior of these dimers versus vancomycin monomer seperations were examined. In addition, parameters that affect dimer based separations such as pH, chiral selector concentration, and organic modifier will be discussed.
 

General Session
7:00 PM-9:00 PM, Sunday, 26 March 2006 Georgia World Congress Center -- Ex. Hall B4, Poster

Division of Analytical Chemistry

The 231st ACS National Meeting, Atlanta, GA, March 26-30, 2006