MEDIThursday, 1 September 2005

9:00 AM-12:20 PM Washington DC Convention Center -- 206, Oral
General Oral Session
Organizer:David Rotella
Presiding:Katerina Leftheris
9:00 AMUnderstanding the role of fluorine in rational drug design
Sandro Mecozzi
9:20 AMThienopyrimidine ureas as novel, potent multi-targeted receptor tyrosine kinase inhibitors
Yujia Dai, Yan Guo, Robin R. Frey, Zhiqin Ji, Michael L. Curtin, Asma A. Ahmed, Daniel H. Albert, Lee Arnold, Shannon S. Arries, Teresa Barlozzari, Joy L. Bauch, Jennifer J. Bouska, Peter F. Bousquet, George A. Cunha, Keith B. Glaser, Jun Guo, Junling Li, Patrick M. Marcotte, Kennan C. Marsh, Maria D. Moskey, Lori J. Pease, Kent D. Stewart, Vincent S. Stoll, Paul Tapang, Neil Wishart, Steven K. Davidsen, Michael R. Michaelides
9:40 AMConstrained analogs of CB-1 antagonists for the treatment of obesity: Design, synthesis, and pharmacology of 1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one derivatives
Roger A. Smith, Soongyu Choi, Zhonghua Zhang, Susan Tomlinson, Harold C. Kluender, Rico C. Lavoie, Jianmei Fan, Stephen J. O’Connor, Brent L. Podlogar, Zahra Fathi, Anish Konkar, Su-Ellen Brown, Astrid A. Ortiz, Jennifer Natoli, Dawn Kelly-Sullivan, Lucinda Milardo, Stacy Hudgins, Christian Raphalides, Jennifer Evenski, Susan Jenkins, Ronald Mays
10:00 AMImplementation of an anesthetized rat cardiovascular safety model as a SAR tool to guide triaging of novel MCHR1 antagonists
Andrew J Souers, James S. Polakowski, Thomas J. Campbell Jr., Jason A. Segreti, Jennifer C. Freeman, Ju Gao, Rajesh Iyengar, Andrew S. Judd, John K. Lynch, Mathew M. Mulhern, Anil Vasudevan, Dariusz Wodka, Gang Zhao, Michael E. Brune, Eugene N. Bush, Robin Shapiro, Victoria E. Knourek-Segel, Brian A. Droz, Sevan Brodjian, Brian D. Dayton, Christopher A Ogiela, Dennis G. Fry, Lisa E. Hernandez, Kennan C. Marsh, Hing L. Sham, Christine A. Collins, Philip R. Kym
10:20 AMDesign, synthesis and binding affinity of some chiral nonsteroidal selective androgen receptor modulators: Bicalutamide analogues of A-ring modified molecules
Renukadevi Patil, Scott J. Fisher, Michael L. Mohler, Casey Bohl, James T. Dalton, Duane D. Miller
10:40 AMDesign and synthesis of potent and subtype-selective PPARα agonists
Ranjit C Desai, Edward Metzger, Joel P. Berger, Karen L. MacNaul, Gaochao Zhou, Tian-quan Cai, Arun K. Agrawal, Samuel D. Wright, David E. Moller, James V. Heck, Peter T. Meinke, Soumya P. Sahoo
11:00 AMFrom selective PPAR ligands to PPAR pan-agonists
Stephen Rafferty, Pierette Banker, Brad R. Henke, Millard H. Lambert, William Oliver Jr., Daniel D. Sternbach
11:20 AMIdentification and X-ray crystal structure of an ERR-alpha inverse agonist reveals a new mechanism of nuclear receptor antagonism
Robert T. Nolte, Liping Wang, Lisa A. Orband-Miller, James M. Way, Julio J. Martin, Ana Maria Roa, Laura Vela, Aaron B. Miller, Timothy M. Willson, William J. Zuercher
11:40 AMPotent and selective benzimidazole glucagon receptor antagonists for the treatment of type 2 diabetes
Ronald M. Kim, Jiang Chang, Elizabeth Rouse, Maria Beconi, Ed Brady, Maria Candelore, Qing Dallas-Yang, Victor Ding, Jasminka Dragovic, Guoqiang Jiang, Zhen Lin, Peggy McCann, Sajjad Qureshi, Richard Saperstein, Deborah Szalkowski, Sharon Tong, Laurie Tota, Michael Wright, Xiaodong Yang, Song Zheng, Milton Hammond, James Tata, Kevin Chapman, Bei Zhang, Emma Parmee
12:00 PM2-Phenyl-4-piperazinylbenzimidazoles as inhibitors of the Gonadotropin Releasing Hormone (GnRH) Receptor
Jeffrey C. Pelletier, Murty Chengalvala, Josh Cottom, Irene Feingold, Lloyd Garrick, Daniel Green, Diane Hauze, Christine Huselton, James Jetter, Wenling Kao, Gregory S. Kopf, Joseph T. Lundquist IV, Charles Mann, John Mehlmann, John Rogers, Linda Shanno, Jay Wrobel

Symposium Grid -- Division of Medicinal Chemistry -- Session Listing

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005