ANYL 130 |
| Raman spectroscopy has proven to be an effective, nondestructive analytical technique due to its structural fingerprinting ability yielding narrow and highly resolved bands. Surface-enhanced Raman scattering is capable of providing highly compound specific vibrational information at the single molecule and single nanoparticle level. Reproducible substrate fabrication is an important factor in for SERS. Among the many substrates being used, metal colloids generally provide the greatest enhancement. Silver nanoparticles are of great interest for SERS applications due to their unique optical properties including an intense surface plasmon absorption in the visible region. Our research explored the fabrication of various SERS substrates to be used for bioanalytical applications. Nanoparticle substrates composed of silver nanoparticles and various polymers were fabricated. We investigated the effect of placing molecules between two metal surfaces and determined which substrates produced the largest enhancement. We also studied the effect of nanoparticle size on the enhancement from each substrate. The fabrication, characterization, SERS activity and applications of the substrates will be discussed. |
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General Papers
7:00 PM-9:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- Hall A, Poster
Division of Analytical Chemistry |