Multidimensional analysis with shaped femtosecond pulses: Identification of conformational and geometric isomers and mixtures using mass spectrometry

ANYL 508

Johanna M. Dela Cruz, delacr14@msu.edu1, Michael Kangas1, Igor Pastirk2, Vadim V. Lozovoy1, and Marcos Dantus, dantus@msu.edu1. (1) Department of Chemistry, Michigan State University, East Lansing, MI 48824-1322, (2) Biophotonic Solutions, Inc, MI
We show how the principle of molecular control using shaped femtosecond laser pulse technology brings about a multidimensional modality to mass spectrometry. The speed and reproducibility of this method allows both qualitative and quantitative identification of chemical sunbstances, including isomers, in pure form or in mixtures, without the need for more complex tandem mass spectrometry approaches. A series of binary phase-shaped laser fields are chosen to unequivocally identify each chemical of interest based on their ability to control fragmentation and ionization pathways and thereby generate statistically different mass spectral fingerprints. Large changes in ion product m/z ratios substantiate selective chemical pathway control for a number of isomeric molecules.
 

General Papers
1:30 PM-4:50 PM, Thursday, 1 September 2005 Washington DC Convention Center -- 153, Oral

Division of Analytical Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005