Silica-based reagents: Suitable for µ-wave applications

ORGN 152

François Béland, fbeland@silicycle.com, Genevieve Gingras, Michel Morin, mmorin@silicycle.com, and Frederic Chaumel. SiliCycle Inc, 1200, ave St-Jean-Baptiste, suite 114, Quebec City, QC G2E 5E8, Canada
In recent years, µ-wave synthesizers have taken organic chemistry by storm. Fast kinetics, higher yields, excellent purities, wide compatibility of solvents, and their applicability to a variety of reactions and applications, makes them very important tools in the laboratory. After their introduction, chemists started to use supported reagents for solution-phase synthesis. The polymer supported reagents commonly used, although very useful, have drawbacks in μ-wave synthesizers: swelling and heat stability. The high temperatures generated inside these synthesizers put stress on these resins. Also, because of the small reaction volumes, the swelling of the resins can be problematic. Silica-based reagents on the other hand, do not suffer from such shortcomings. They are heat resistant and they do not swell. We will present different reactions (amide synthesis, reductive amination, Suzuki couplings) using silica-based reagents as well as electrophile, nucleophile, and metal scavenging reactions that demonstrate the effectiveness of these reagents in µ-wave applications.