ANYL 121 |
| The rise of Process Analytical Technology (PAT) has been significant in the pharmaceutical industry in recent years. One goal of PAT is to increase process and product understanding by collecting real-time chemical and physical information during processing. A useful application of PAT is to employ Near-Infrared Spectroscopy (NIR) to monitor various unit operations during process development in a pharmaceutical product pilot plant. For instance, an in-line NIR probe situated inside a wet granulator can be used to obtain process signatures which provide an indication of consistency across different batches. An in-line NIR can be calibrated to predict and display total percent moisture during fluid bed drying. In a blending case, on-line NIR can monitor compositional variability over the entire blending time rather than only the few time points that traditional sampling would allow. To monitor drug content during tablet compression, NIR applications can be an in-line probe in the feed hopper of the press to verify uniformity of the blend and/or an at-line method where NIR scans the finished tablet for uniformity. This poster highlights several examples of NIR implementation for processes as described above. |
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General Papers
7:00 PM-9:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- Hall A, Poster
Division of Analytical Chemistry |