Toward the formation of metallointercalator-based DNA architectures

ORGN 485

Hanadi F. Sleiman, and Roxanne E. Kieltyka, Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 2K6, Canada
The construction of nano-objects from DNA has evolved greatly from the original topological nucleic acid structures first devised by Seeman. Novel architectures incorporating a variety of functional vertices have since been constructed for the generation of functional materials composed of DNA. Our research hopes to expand this library of architectures with the addition of a novel class of functional DNA networks; those that are supported by intercalating molecular squares. Our design encompasses the use of supramolecular platinum DNA intercalation agents to drive the organization of DNA duplexes on the nanoscale. Synthesis of the mono-metallic, [Pt(PIP)(py)2]2+PF6 (PIP=Phenanthroimidazole), and the molecular square complex, [Pt(4,4'-dipyridyl)(PIP)(OTf)2]4,and their respective interactions with DNA will be presented.

Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster

8:00 PM-10:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005