The work presented here deals with the specifically tailored tetramethoxy calixarene tetraurea and its response to Na+ and K+ ions. This conformationally flexible calixarene locks into a cone conformation in the presence of Na+ allowing dimerization and subsequent encapsulation of guest molecules. In the presence of K+ the calixarene flips two anisole units and adopts a 1-3 alternate conformation releasing the target substrate. We envision this research leading to the active drug delivery system using the physiological Na+/K+ gradient as a driving force. This research could: lower the required dosage of a drug, accelerate drug delivery and target multidrug-resistant tumors. Preliminary studies including the synthesis, thermodynamics of guest encapsulation and transport efficiency will be discussed.
Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster