Olefin metathesis in dynamic combinatorial library of cyclic peptidomimetics

ORGN 604

Tammy K. C. Low, Jedidiah M. Hastings, and Eric J. Enholm, enholm@chem.ufl.edu. Department of Chemistry, University of Florida, Gainesville, FL 32611
Our research goal is to generate a dynamic combinatorial library of novel cyclic peptidomimetics using reversible cross-metathesis. The constituents of our library are made by cross-metathesis of amino acid precursors with a cyclic scaffold. A model study has already demonstrated the reactivity and reversibility of the cross-metathesis reaction in our system. We are currently synthesizing various cyclic scaffolds and amino acid derivatives possessing terminal olefin moiety. A small library of cyclic peptidomimetics has been generated, and different templates are now being examined to determine the effects on the dynamic equilibrium.


Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster

8:00 PM-10:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005