Synthetic ligand-gated channels

ORGN 445

Usha Devi, and Simon J Webb, School of Chemistry, University of Manchester, Faraday Tower, Sackville Street, Manchester, M60 1QD, United Kingdom
In biological systems controlled communication between cells is crucial for the functioning of multicellular organisms. Cells communicate by releasing chemical messengers, a process which requires transport of chemicals through the cell membranes (phospholipid bilayers). In order to understand this crucial biological process, we aim to mimic transport through biological membranes. A novel strategy of metal-mediated self-assembly will be applied to reversibly construct synthetic pores within phospholipid bilayer membranes. Pores will be formed when metal complexes (‘hinges') are added to the membrane, triggering the self-assembly of pores from membrane-spanning molecules (trans-A2B2 porphyrin based ‘panels', below) using well-established principles from supramolecular and coordination chemistry. Model studies have been carried out in organic solvents and binding constants have been determined. Complexation to the hinge and assembly of the panels have been monitored using 1H NMR spectroscopy and UV-visible spectroscopy and the structure of the products elucidated.







Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster

8:00 PM-10:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005