Multi-component reaction has played a significant role in synthetic chemistry. Particularly, Mannich reaction is very useful for this purpose. This reaction can provide highly functionalized b-amino ketone derivatives. Many catalysts have been discovered to perform an effective three component Mannich reaction. Our work on bismuth nitrate-catalyzed organic transformations has proved very fruitful for the facile synthesis of b-amino ketones starting from aldehydes, ketones and carbamates.
New Reactions and Methodology, Materials, Total Synthesis, Process R&D
8:00 PM-10:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- Hall A, Poster