Bismuth nitrate-catalyzed multi-component reactions

ORGN 104

Bimal K. Banik, and Ramon Garza. Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX 78541

Multi-component reaction has played a significant role in synthetic chemistry.  Particularly, Mannich reaction is very useful for this purpose.  This reaction can provide highly functionalized b-amino ketone derivatives.  Many catalysts have been discovered to perform an effective three component Mannich reaction.  Our work on bismuth nitrate-catalyzed organic transformations has proved very fruitful for the facile synthesis of b-amino ketones starting from aldehydes, ketones and carbamates.