Nicholas reactions for combinatorial chemistry

ORGN 602

Jesse A. Teske, and Alexander Deiters, Department of Chemistry, North Carolina State University, 2620 Yarbrough Drive, Box 8204, Raleigh, NC 27695
The employment of tandem reactions in combinatorial chemistry is an expedient way to produce diverse arrays of compounds. We are utilizing the Cobalt mediated Nicholas reaction coupled with subsequent Pauson-Khand reactions or [2+2+2] cyclotrimerizations to access mono- and bi-cyclic frameworks. The obtained cyclopentenone derivatives and aromatic compounds possess core structures found in a variety of natural products and biologically active compounds. Conducting these tandem reactions on a solid-support will greatly facilitate their application in combinatorial and medicinal chemistry. Here, we report initial developments towards this goal.

Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster

8:00 PM-10:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005