Studies towards the stereoselective synthesis of FR-900482

ORGN 677

Zhenghua Wang,, Ning Shangguan, and Lawrence J Williams. Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854
FR-900482 is an antitumor antibiotic isolated from Streptomyces sandaensis. Its highly promising antitumor activity in human clinical trials and unique structure FR-900482 make it an attractive synthetic target for the application of new methodologies. Progress towards a stereoselective synthesis of FR-900482 utilizing spirodiepoxides will be presented.

Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster

8:00 PM-10:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005