Microwave-enhanced cross-coupling reactions involving potassium organotrifluoroborates

ORGN 151

George W. Kabalka, kabalka@utk.edu, Departments of Chemistry and Radiology, University of Tennessee, Buehler Hall, Knoxville, TN 37996-1600 and Mohammad Al-Masum, Almasum@ion.chem.utk.edu, Departments of Chemistry and Radiology, The University of Tennessee, Buehler Hall, Knoxville, TN 37996-1600.
The palladium catalyzed cross-coupling reaction between organoboron compounds and organic halides provides a powerful tool for the formation of carbon-carbon bonds. Recently, the utility of potassium organofluoroborates as intermediate in the synthesis of biaryl compounds using cross-coupling methodology has become widely recognized. The application of microwave technology to cross-coupling reactions involving potassium trifluoroborate has not been described. We wish to report that the palladium catalyzed coupling reactions of potassium aryltrifluoroborates with aryl iodides occur rapidly and produce the coupled products in excellent yields.