Towards unimolecular artificial channels using peptide nanostructures

ORGN 40

Normand Voyer, normand.voyer@chm.ulaval.ca, François Otis, francois.otis@chm.ulaval.ca, Joëlle Martin, Julie Richer, Eric Biron, and Jean-Christophe Meillon. Department of Chemistry and CREFSIP, Université Laval, Quebec City, QC G1K 7P4, Canada
In this presentation, we will describe our approach towards artificial ion channels that exploit nanoscale peptide frameworks to organize several macrocyclic ionophores in a tubular fashion. We will also report our most recent results on the mode of action of such channels and their selective engineering into more elaborated devices. More specifically, we will focus on the modification of the N- and C-terminal positions to enhance membrane stabilization and to incorporate biological recognition groups.
 

Membrane Active, Synthetic Organic Compounds
1:30 PM-5:05 PM, Sunday, 28 August 2005 Washington DC Convention Center -- Ballroom C, Oral

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005