Towards the enantioselective synthesis of Swansonine

ORGN 197

Haibing Guo, haibingguojj@yahoo.com and George A. O'Doherty, george.odoherty@mail.wvu.edu. C. Eugene Bennett Department of Chemistry, West Virginia University, 284 Prospect Street, 217 Clark Hall, Morgantown, WV 26506
Swansonine is a bicyclic polyhydroxylated alkaloid with four stereo centers, which was isolated from the fungal culture Rhizoctonia leguminicola. Swansonine shows wide biological activities. These includes against cancer cells, HIV infected cells and is a potent inhibitor of lysosomal a-mannosidase. The unique structure of Swansonine attracted our synthesis interst. Our current synthetic effort toward Swansonine will be presented.

 

New Reactions and Methodology, Materials, Total Synthesis, Process R&D
8:00 PM-10:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- Hall A, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005