We have demonstrated various methods for the synthesis of b-lactams, anticancer agents and several other biologically active compounds. Many of these products are derived from aromatic nitro compounds. In continuation of our research in these areas, we describe herein a facile nitration of the aromatic components in several substituted b-lactams with bismuth nitrate impregnated with clay. Microwave-irradiation has made the procedure faster. Using this method, synthesis of a number of aryl nitro substituted cis and trans b-lactams has been accomplished. The conventional mixed acid is not suitable for this kind of study. These derivatives are important starting materials for the synthesis of heterocycles.
New Reactions and Methodology, Materials, Total Synthesis, Process R&D
8:00 PM-10:00 PM, Sunday, 28 August 2005 Washington DC Convention Center -- Hall A, Poster