Approaches to the synthesis of indole-2,3-quinodimethane

ORGN 632

Alison Rinderspacher, and Gordon W. Gribble, Department of Chemistry, Dartmouth College, 6128 Burke, Hanover, NH 03755

Countless biologically active indole and carbazole alkaloids have been isolated from natural sources.  Indole-2,3-quinodimethane (1) is a reactive intermediate that has been generated by several groups for the synthesis of indole-containing natural products.  However, no stable example of indole-2,3-quinodimethane has been synthesized.  The paper will present our approaches to the generation of potentially stable analogs of indole-2,3-quinodimethane.





Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster

8:00 PM-10:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005