Approaches to the synthesis of indole-2,3-quinodimethane

ORGN 632

Alison Rinderspacher, Alison.Rinderspacher@dartmouth.edu and Gordon W. Gribble, ggribble@dartmouth.edu. Department of Chemistry, Dartmouth College, 6128 Burke, Hanover, NH 03755

Countless biologically active indole and carbazole alkaloids have been isolated from natural sources.  Indole-2,3-quinodimethane (1) is a reactive intermediate that has been generated by several groups for the synthesis of indole-containing natural products.  However, no stable example of indole-2,3-quinodimethane has been synthesized.  The paper will present our approaches to the generation of potentially stable analogs of indole-2,3-quinodimethane.

 

 

 

 

Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005