Studies towards the total synthesis of Tedanolide: Synthesis of C8-C17 fragment

ORGN 173

Vijay Kumar Nyavanandi, vijaykumarn@drreddys.com1, Srinivas Nanduri, nandurisrinivas@drreddys.com1, Naidu Andra, anaidu48@yahoo.co.in2, and Javed Iqbal, javediqbal@drreddys.com1. (1) Discovery Research, Dr Reddy's Laboratories Limited, Miyapur, Bollaram Road, Hyderabad - 500 049, India, (2) Department of Chemistry, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad - 500072, India
The kingdom of natural products has been an invaluable source of novel and potent leads in the discovery of several antibiotic, antihyper-cholestremic and antitumor agents, etc. Recently macro cyclic marine natural products have become an important source for potent antitumor agents with unique structural features. Tedanolide, an architecturally coplex marine macrolide, isolated from Tedania ignis has displayed potent antitumor activity. Low natural abundance coupled with potent biological activity has prompted us to pursue the synthesis of this macrolide. Proposed synthetic strategy and synthesis of C8-C17 fragment will be presented.