Highly stereoselective synthesis of 2,5-disubstituted 3-vinylidene tetrahydrofurans via Prins-type cyclization

ORGN 128

Yong Seo Cho, ys4049@kist.re.kr, Chul Shin, Ae Nim Pae, Joo Hwan Cha, and Hun Yeong Koh. Biochemicals Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul, 130-650, South Korea
A Novel synthetic methodology of 2,5-disubstituted tetrahydrofurans having allenyl group at 3-position via Prins-type cyclization was developed. The reaction led to excellent selectivies and modern to high yields.