Synthesis and catalytic application of superparamagnetic Fe2O3 nanoparticle-supported Ti-BINOLate complex

ORGN 376

Jinda Fan, and Yong Gao, Department of Chemistry and Biochemistry, Southern Illinois University, 1245 Lincoln Drive, Carbondale, IL 62901
Synthesis of superparamagnetic Fe2O3 nanoparticles is described. A micelle polymerization strategy was used to synthesize core/shell magnetic nanoparticles having an iron oxide core surrounded by a layer of polystyrene shell. BINOL was then tethered to the polymer-surrounded nanoparticles via an ether bond to generate a Ti-BINOLate complex. This magnetic nanoparticle-supported Ti-BINOLate complex was used for catalyzing asymmetric alkylation of benzaldehyde with Et2Zn in good yields and high enantioselectivity. An advantage of our approach is that the expensive chiral catalyst can be easily recovered and recycled via applying an external permanent magnet.


Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster

8:00 PM-10:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005