Fluorous-enhanced multicomponent reactions

ORGN 157

Wei Zhang, w.zhang@fluorous.com1, Yimin Lu, y.lu@fluorous.com2, and Christine H-T. Chen2. (1) University of Pittsburgh Applied Research Center, Fluorous Technologies, Inc, 970 William Pitt Way, UPARC, Pittsburgh, PA 15238, (2) Discovery Chemistry, Fluorous Technologies, Inc, 970 William Pitt Way, UPARC, Pittsburgh, PA 15238
Reaction sequences containing multicomponent reactions (MCRs) and post-condensation reactions have been widely used in the synthesis of diversified library scaffolds. Recently, fluorous tagging strategy has been introduced to MCRs to simplify reaction mixture purifications. The MCR product bearing a fluorous tag can be easily isolated from non-fluorous components by fluorous solid-phase extraction (F-SPE). The fluorous tag can be removed during the post-condensation reaction. This presentation describes microwave-assisted fluorous synthesis of unique small molecule libraries using reaction sequences such as Ugi/de-Boc/cyclization and [3+2] cycloaddition/Suzuki coupling reactions.