Synthesis of thymidin dimer-building blocks and investigations on the photodamaged DNA

ORGN 420

Benjamin Hankeln,, Naturwissenschaftliche Fakultät IV Chemie / Pharmazie, Universität Regensburg, Universitätsstr. 31, Regensburg, Germany, Olaf Wiest,, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556-5670, and Burkhard Koenig,, Naturwissenschaftliche Fakultät IV, Chemie und Pharmazie, University of Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.
The cyclobutane pyrimidine dimer (CPD) is suspected to be one of the causes of skin cancer and has therefore attracted lot of scientific attention. As an interesting mode of action for new skin cancer drugs the natural photolyase was investigated, and several examples for artificial photolyases were presented in recent years. The synthesis of the cis-syn-thymidine dimer building block suitable for a solid-phase DNA synthesis is still a major problem in this area of research. In this contribution, several synthetic routes are compared. The building blocks are then incorporated into DNA oligomers. These DNA strands containing the photolesion are subject to further examinations, including DNA repair studies.


Bioorganic, Metal-Mediated Reactions, and Molecular Recognition
8:00 PM-10:00 PM, Tuesday, 30 August 2005 Washington DC Convention Center -- Hall A, Poster

8:00 PM-10:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005