Electrode-assisted room-temperature Heck reaction

ORGN 136

Jun Tian, juntian@wuchem.wustl.edu and Kevin D. Moeller, moeller@wuchem.wustl.edu. Department of Chemistry, Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130
An electrochemically assisted, room-temperature Heck reaction has been developed. The use of electrodes dramatically reduces reaction times compared to the corresponding chemical methods, and results in similar good yields. The reaction is applicable for aryl bromides and iodides, however, aryl chlorides are not reactive under the reaction conditions. The reaction products isolated are predominantly trans isomers. Additive and solvent effects will be also discussed.