Solution/solid phase annulation (SPAn™) technology: Synthesis of 1,4-diazapine- and 1,4-piperazine-2,5-diones

ORGN 600

Rosalyn Green, rgreen@adolor.com, Blanca Martinez-Teipel, bmartinez@adolor.com, and Roland E. Dolle. Department of Chemistry, Adolor Corporation, 700 Pennsylvania Dr, Exton, PA 19341
Methods for the rapid derivatization of amines to synthesize I and II were developed as part of the title technology platform. I was synthesized from the acrylamides of resin-bound aminoacids. II was synthesized from the a-bromoacetamides of resin-bound aminoacids. The synthesis of these precursors, their reaction with amines, and cyclization to the title compounds will be presented.

 

Asymmetric Reactions, Heterocycles, Aromatics, Combinatorial, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 31 August 2005 Washington DC Convention Center -- Hall A, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 29 August 2005 Washington DC Convention Center -- Hall A, Sci-Mix

Division of Organic Chemistry

The 230th ACS National Meeting, in Washington, DC, Aug 28-Sept 1, 2005