AGFD 65 |
| Skin cancer is the fastest growing type of cancer in the US population due to excessive sun exposure. Skin cancer can be inhibited by topical sunscreens which absorb the UV light or by antioxidants (aoxs) which react with the free radicals produced in the skin by UV. In a 30 week study, hairless mice were exposed to ½ the minimal erythemal dose of UV-B radiation three times/week. Topical aoxs in an organic solvent vehicle were applied either singly or in combination to the dorsal surface prior to each UV exposure. The groups were control with no UV, control with vehicle and UV, experimental groups with UV-ascorbic acid (C), tocopherol (E), superoxide dismutase (SOD), selenium yeast (SeY), C+E, and C+E+SeY. Tumor progression (1mm diameter or larger) and skin wrinkling were monitored weekly. At the end of the study, the animals were sacrificed and skin was removed for analysis. Lipid and protein oxidation were measured in skin homogenates. Epidermal thickening and dermal cellularity were also assayed. The combinations were generally more effective than the single compounds. A combination of a topical sunscreen and a mixture of aoxs would appear to be the best regimen for the prevention of human skin cancer.
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Sci-Mix
8:00 PM-10:00 PM, Monday, 14 March 2005 Convention Center -- Sails Pavilion, Sci-Mix
Division of Agricultural & Food Chemistry |