COMP 264 |
| A protein structure defines a series of functional requirements necessary for generating that structure. A multiple sequence alignment provides a number of solutions to these requirements. By comparing thousands of positions across hundreds of multiple sequence alignments, one can derive a small number of discrete functional classes, and a fitness of each amino acid for each class. Bayesian inference from these classes reproduces standard substitution matrices when applied to pair-wise amino acid comparisons, but extends naturally to conservation analysis of multiple residues observed at a specific position in a multiple sequence alignment. |
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Applications of Information Theory in Chemistry
8:50 AM-11:30 AM, Wednesday, 16 March 2005 Convention Center -- Room 2, Oral
Division of Computers in Chemistry |