Using biological information to guide chemistry


David Edwards, Accelrys, Inc, 9685 Scranton Rd, San Diego, CA 92121
Completion of the sequencing of the human genome coupled with large scale structure determination projects and advances in the high-throughput generation of annotated, computational models provides a plethora of information. This information often includes key observations on protein-ligand interactions. Chemists who seek to use this biological information to design or enhance the affinitity and selectivity of drug candidates face a number of challenges. Methods by which this data can be used to elucidate the requirements for selective binding to a particular target will be discussed, with a particular emphasis on examples of where this data can accelerate understanding and thus the drug discovery process.

Chemogenomics: What It Is And What It Is Not
9:00 AM-11:30 AM, Wednesday, August 25, 2004 Pennsylvania Convention Center -- 201C, Oral

Biotechnology Secretariat

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004