Portal between biological and chemical worlds: Empiricism driving drug discovery


John Overington, Inpharmatica Ltd, 60 Charlotte St., London W1T 2NU, United Kingdom
The link between the biological and chemical worlds is of central importance in many fields, not least that of healthcare. A major focus in biology are genes/proteins and the networks and pathways describing their interactions and functions; similarly, within chemistry there is much interest in efficiently identifying drug-like compounds that specifically interact with these targets. However there has been relatively little research explicitly directed at understanding the linkages between these two domains. Key to our work in this area has been the construction of a large and general database linking pharmacological activities of compounds through to their targets, and understanding how particular privileged chemotypes recognise their cognate receptors. Application of these rules and databases leads to rapid, economic, and effective identification of quality target and lead combinations for subsequent pharmacological validation. These data have also been mapped to the currently drugged genome and launched drugs, and aspects of the analysis and implications of this study will be outlined.

Chemogenomics: What It Is And What It Is Not
9:00 AM-11:30 AM, Wednesday, August 25, 2004 Pennsylvania Convention Center -- 201C, Oral

Biotechnology Secretariat

The 228th ACS National Meeting, in Philadelphia, PA, August 22-26, 2004