Investigation of pharmaceutical biocolloids using high-resolution ultrasonic spectroscopy

COLL 78

Sinead Hickey, Vitaly Buckin, G. R. Ivanitskii, and M. J. Lawrence. Department of Chemistry, University College, Dublin, Belfield, Dublin 4, Ireland
High-Resolution Ultrasonic Spectroscopy (HR-US) is a novel approach for the analysis of materials, in a non-invasive manner and provides information regarding their microstructure. In the present work we use HR-US to examine two colloidal systems. The first system involved construction of a pseudo-ternary phase diagram for a system consisting of pharmaceutically accepted components, water/isopropyl myristate/soybean lecithin and a cosurfactant, propanol. The transition points and pre-transition aggregation (including microemulsion phase) and particle size were measured for various water/oil/surfactant concentrations. The second system involved examination of the effect of dissolved gases in a fluorocarbon-based oxygen delivery emulsion, Pftoran (JSC SPF PERFTORAN). Sedimentation and effects of saturation with various respiratory gases were measured. Changes in ultrasonic velocity and attenuation in the MHz frequency range was monitored for both systems using a High-Resolution Ultrasonic Spectrometer (Ultrasonic Scientific Ltd.). The data obtained provided information on the structure of the micelles present in each case.