ORGN 9 |
| John P. Toscano, Department of Chemistry, Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218 |
| The biochemistry of the nitroxyl system (NO-/HNO), the one-electron reduced congener of nitric oxide, has recently received significant attention, especially as a potential alternative to current treatments of cardiac failure. Compared with nitric oxide, however, much less is known about the fundamental solution chemistry of this deceptively complicated system. Relatively few precursors to nitroxyl exist and the direct observation of HNO has been limited mainly to gas phase and matrix studies. This presentation will focus on the development of new nitroxyl precursors as well as on the reactivity of acyl nitroso compounds, transient electrophiles that react with nucleophiles to yield NO-/HNO. |
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Theory and Experiment in Modern Organic Chemistry
8:50 AM-12:00 PM, Sunday, August 22, 2004 Pennsylvania Convention Center -- Ballroom A, Oral
Division of Organic Chemistry |