COLL 38 |
| Dan L. Sackett, Hacene Boukari, Norman Watts, and Ralph Nossal. Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892 |
| Tubulin is the subunit of microtubules, and normally reversibly polymerizes in the indefinite helical lattice that characterizes the wall of the microtubule. A new group of natural product antimitotics, composed of small peptides and depsipeptides, is represented by cryptophysin, hemiasterlin, and dolastatin. These compounds bind to tubulin, interfere with polymerization and induce formation of unusual ring polymers, composed of 8 or 14 tubulins. Despite their similarity in structure, these rings differ from each other in several ways, including stability and uniformity. In addition, dolastatin ring polymers readily associate to form larger structures with characteristic lengths of micrometers. |
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Bio-Colloids
2:00 PM-4:30 PM, Sunday, March 28, 2004 Marriott -- Grand Ballroom J, Oral
Division of Colloid and Surface Chemistry |