COLL 510 |
| Jamie Tsung, Lavipharm Laboratories Inc, 69 Princeton-Hightstown Road, East Windosr, NJ 08520 and Diane J. Burgess, Pharmaceutical Sciences, University of Connecticut, 372 Fairfield Road, Storrs, CT 06269. |
| Biodegradable colloidal polymeric drug delivery systems have gained prominence due to their controlled release drug profiles, consequently reducing side effects and improving patient compliance. A major challenge is to efficiently deliver drugs to specific sites in the body. Surface modification of particles provides a strategy to reduce adsorption of plasma protein, altering the biodistribution of the drug delivery system and improving targeting ability by providing site-specific affinity. Examples of model surface modified particulate systems that improve targeted delivery will be reviewed. This presentation will focus on particles prepared with biodegradable polymer poly(lactide-co-glycolide acid) (PLGA) and surface modified with gelatin. Preparation, characterization, methods, advantages and limitations, use and recent developments will be discussed. |
|
Symposium in Memory of Arthur W. Adamson
2:00 PM-5:20 PM, Thursday, April 1, 2004 Marriott -- Orange County 3, Oral
Division of Colloid and Surface Chemistry |