I&EC 237 |
| W. Y. Shih1, W-H. Shih1, G. Campbell2, and R. Mutharasan2. (1) Department of Materials Science and Engineering, Drexel University, Market and 31st, Philadelphia, PA 19104, (2) Department of Chemical Engineering, Drexel University, Market and 31st, Philadelphia, PA 19104 |
| Miniaturized highly piezoelectric cantilevers offer the advantages of simple electrical detection and better capabilities to withstand damping in water. It is especially suitable for in-situ aqueous detection of bioagents or microbes. Binding of antigens to the antibody immobilized on the cantilever surface increases the cantilever’s mass and reduces its resonance frequency, which is detected by monitoring the resonance frequency shift. Detection of cells, proteins, and specific antigen-antibody binding using a lead zirconate titanate (PZT)/stainless steel cantilever has been demonstrated. Application to direct E coli quantification using PZT/glass and lead magnesium niobate-lead titanate (PMN-PT)/glass cantilevers will be presented. Simultaneous detection of multiple antigens, detection selectivity and sensitivity will be examined using array cantilevers. Mass detection sensitivity with respect to cantilever size and the fabrication and characterization of the miniaturized PMN-PT/glass cantilevers will also be discussed. |
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Nanotechnology and the Environment
1:30 PM-4:35 PM, Wednesday, March 31, 2004 Marriott -- Grand Ballroom F, Oral
Division of Industrial and Engineering Chemistry |