COLL 532 |
| Henry Hess1, John Clemmens1, Robert Doot1, Antje Hanisch1, Carolyn M. Matzke2, George D. Bachand2, Bruce C Bunker2, and Viola Vogel1. (1) Center for Nanotechnology and Department of Bioengineering, University of Washington, Box 351721, Seattle, WA 98195, (2) Biomolecular Materials and Interfaces, Sandia National Laboratories |
| Molecular motors, which can actively transport molecules and exert forces, open new avenues for nanotechnology. Our approach is to utilize motor proteins to assemble hybrid devices with micro- and nanoscale dimensions. In this effort we are inspired by the diverse applications nature has found for molecular motors, ranging from intracellular transport to the actuation of muscles. We will present prototypes of molecular shuttles (a nanoscale transport system), a piconewton forcemeter, and a novel surface imaging method based on self-propelled probes. In these systems, motor proteins are immobilized on microfabricated surfaces and transport functionalized microtubules. Currently, we are exploring the application of the motor protein-based molecular shuttles as transport elements in biosensors with the goal to increase sensitivity and speed of detection. We will discuss our first proof-of-principle experiments, which take advantage of our improved understanding of the critical elements in the design of such hybrid devices. |
|
Nanoscience and Nanotechnology
2:00 PM-5:15 PM, Thursday, April 1, 2004 Marriott -- Orange County 5, Oral
Division of Colloid and Surface Chemistry |