COLL 339 |
| Baohua Yue1, Chien-Yueh Huang2, Mu-Ping Nieh3, Charles J Glinka4, and John Katsaras3. (1) Department of Chemistry and Environmental Science, New Jersey Institute of Technology, 161 Warren Street, Newark, NJ 07102, (2) Otto H. York Department of Chemical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, (3) Steacie Institute for Molecular Sciences, National Research Council, Chalk River, ON K0J1J0, Canada, (4) Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD |
| Unilamellar vesicles (ULVs) consisting of a single lipid bilayer are of special interests as drug delivery vehicles. We report on a system composed of short- and long-chain phospholipids, dihexanoyl (DHPC) and dimyristoyl phosphorylcholine (DMPC), respectively, that spontaneously forms ULVs of narrow size distribution. Doping mixtures of DMPC/DHPC with the negatively charged lipid dimyristoyl phosphorylglycerol (DMPG) or simple cations such as Na+ and Ca++, or both, led to the spontaneous formation of highly stable ULVs. Small-angle neutron scattering (SANS) and dynamic light scattering (DLS) were employed to systematically investigate the various mesophases. The spontaneously formed ULVs are stable for periods of days, weeks and months. |
|
Bio-Colloids
2:00 PM-4:40 PM, Tuesday, March 30, 2004 Marriott -- Orange County 3, Oral
Division of Colloid and Surface Chemistry |