COLL 481 |
| Maria Hepel and Magdalena Stobiecka. Department of Chemistry, State University of New York at Potsdam, 44 Pierrepont Avenue, Potsdam, NY 13676 |
| Ion-channel molecules with ion-gating properties play an important role in biological membranes allowing for controllable transport of species across cell membranes. We have studied the behavior of such molecules in the adsorbed state on solid electrodes, either by incorporating them into a supported lipid bilayer film (BLM), e.g. gramicidin, or by self-assembling them directly on a gold substrate electrode. In the latter group, glutathione SAM was found to show remarkable gating properties toward redox probe ions (ferricyanide) and metal ions (Cu2+, Ni2+, Pb2+). In the present study, we focused on modeling conformational transformations of glutathione molecules adsorbed on Au and tuning their ion-gating properties by controlling the electric field, local pH, and interacting with glutathione, metal ions. The behavior of glutathione is compared to aliphatic carboxymercaptans. The measurements were performed using the EQCN technique, allowing for fast determination of adsorption transients and interactions of the adsorbate with solution species. |
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Symposium in Memory of Arthur W. Adamson
8:30 AM-11:50 AM, Thursday, April 1, 2004 Marriott -- Orange County 4, Oral
Division of Colloid and Surface Chemistry |