COLL 428 |
| John C. Conboy and Jin Liu. Department of Chemistry, University of Utah, 315 S. 1400 E. RM 2020, Salt Lake City, UT 84112 |
| A lipid membrane is the physical shell which encapsulates all cellular organisms. The use of planar supported analogous of lipid bilayers have been used as models for studying membrane structure and function, as biocompatible substrates for biosensors and as nonfouling protein resistant surfaces. Recent studies in our laboratory indicate that sum-frequency vibrational spectroscopy (SFVS) is a powerful tool for measuring the structure, phase transition temperature and lipid dynamics in these systems. SFVS has been used to measure the orientation of the lipid fatty acid chains and phosphocholine head groups. The phase transition temperature of a single lipid bilayer has been determined by SFVS for several lipids and agrees will with bulk measurement performed by differential scanning calorimetry. Lipid flip-flop has also been studied by SFVS showing for the first time, without the use of a molecular probe, that the interchange of lipid species between membrane leaflets is reasonably fascicle. |
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Vibrational Analyses of Dry and Wet Surfaces
2:00 PM-5:30 PM, Wednesday, March 31, 2004 Marriott -- Grand Ballroom H, Oral
Division of Colloid and Surface Chemistry |