COLL 388 |
| Michèle Léonard1, Alain Durand1, Terri A. Camesano2, Emmanuelle marie1, and Edith Dellacherie1. (1) LCPM, Ecole Nationale Superieure des Industries Chimiques, 54000 Nancy, France, (2) Department of Chemical Engineering, Worcester Polytechnic Institute, 100 Institute Rd., Goddard Hall, Worcester, MA 01609 |
| Polymeric surfactants were synthesized by covalent attachment of hydrophobic groups onto dextran. The associative behavior is controlled by both the substitution ratio and the hydrophobicity of grafted groups. The surface active properties of the modified polysaccharide were evidenced by surface/interfacial tension measurements and determination of adsorption isotherms onto polymeric particles. The effects of adsorbed layers on the properties of latex dispersions were characterized in terms of the stability of the dispersions toward added electrolyte and of protein adsorption. Oil-in-water emulsions were prepared using the polymeric surfactants as stabilizers, at various oil volume fractions. The droplet size and emulsion ageing were linked to the chemical structure and the amount of polymer in the aqueous phase. The dextran-based surfactants were applied to the emulsion polymerization of styrene. Their applicability in the preparation of poly(lactic acid) (PLA) nanospheres and dry emulsions was also investigated. The resulting nanoparticles were evaluated as drug delivery systems. |
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Symposium in Memory of Arthur W. Adamson
8:30 AM-12:10 PM, Wednesday, March 31, 2004 Marriott -- Orange County 4, Oral
Division of Colloid and Surface Chemistry |