COLL 408 |
| Masaru Eguchi, Tooru Ooya, and Nobuhiko Yui. School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Tatsunokuchi, Ishikawa, 923-1292, Japan |
| Three types maltose-polyrotaxane conjugates (% of α-CD threading: 20, 38 and 50) were synthesized, and the effects of both multivalency and supramolecular mobilities were evaluated. The binding affinity of the maltose-polyrotaxane conjugates with concanavalin A (Con A) was investigated by inhibition of hemagglutination (HIA). The binding affinity of maltose-polyrotaxane containing 38% α-CDs threading with 244 maltose goups was 3000 times greater than maltose itself, while that of maltose-poly(acrylic acid) conjugate (Mn: 25000) with 235 maltose groups was about 170 times. The HIA was proportional to the mobility of maltose, which was estimated by spin-spin relaxation time (T2) of maltose C(1) proton in the polyrotaxane. Therefore, it was concluded that mobility of maltose groups along the polyrotaxane structure contributes to enhanced Con A recognition. |
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“Smart” Polymers on Surfaces and Colloids
8:30 AM-11:40 AM, Wednesday, March 31, 2004 Marriott -- Grand Ballroom J, Oral
Division of Colloid and Surface Chemistry |