COLL 300 |
| Edgar J. Acosta, Department of Chemical Engineering, University of Oklahoma, 100 East Boyd, Sarkeys Engineering Center, room T-334, Norman, OK 73019, Thu Nguyen, Chemical Engineering and Materials Science, University of Oklahoma, 100 E. Boyd room T-334, Norman, OK 73072, Jeffrey H. Harwell, College of Engineering, University of Oklahoma, 202 W. Boyd, Carson Engineering Center, Room 107, Norman, OK 73019, and David A Sabatini, Institute of Applied Surfactant Research, University of Oklahoma, 100 East Boyd Street, Sarkeys Energy Center, Room T-335, Norman, OK 73019. |
| Microemulsion systems have been studied in the last 10 years as vehicles for drug delivery. Drugs like lidocaine and amphotericin are now available in microemulsion formulations. Cosmetics and vitamins also are being formulated in microemulsion systems. The advantages of microemulsion systems include the ability to deliver both oil and water soluble actives, the ability of more easily penetrate membranes due to the nanoscale size of the oil aggregates, the ability to protect the drug from being degraded by gastric juices in case of oral delivery, and the improved permeability in tissues. Microemulsion systems have also been reported to provide more efficient delivery than some commonly used solvent systems. The main issue limiting widespread use of this technology is that most microemulsion systems require medium chain alcohols. These alcohols are either toxic or are an irritant to some tissues. Additionally, certain nonionic surfactants used in some systems have shown some levels of carcinogenicity after chronic exposure. Here we describe alcohol-free microemulsion systems that use biocompatible "hydrophilic and lipophilic linkers." The surfactant is egg-extracted lecithin, the hydrophilic linker is hexyl glucoside and the lipophilic linker is sorbitol monoleate. This formulation shows good efficiency at solubilizing oils of interest for drug delivery systems (e.g. isopropyl myristate and methyl oleate). This formulation is studied as a function of surfactant concentration, temperature and pH. These studies allow an assessment of the performance of the formulation for different delivery techniques (transdermal, intramuscular, oral). Drug permeation tests through artificial skin are also reported along with observations on the effect of the formulation on the morphology of the skin. |
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Bio-Colloids
8:30 AM-10:30 AM, Tuesday, March 30, 2004 Marriott -- Orange County 3, Oral
Division of Colloid and Surface Chemistry |