COLL 409 |
| Nicholas L Abbott, Department of Chemical and Biological Engineering, University of Wisconsin, 1415 Engineering Drive, Madison, WI 53706-1691 and Jeff Brake, Department of Chemical Engineering, University of Wisconsin, 1415 Engineering Drive, Madison, WI 53706. |
| This presentation will describe an exploratory investigation of the self-assembly of phospholipids on the surfaces of thermotropic liquid crystalline substrates, and coupling of interfacial phenomena within these phospholipid films to the orientational behaviors of the supporting thermotropic liquid crystals. Procedures leading to the formation of these biomimetic interfaces will be reported along with observations of the time-dependent orientational behavior of the liquid crystal. We will also report that it is possible to couple the orientational behavior of thermotropic liquid crystals to a variety of different biologically relevant phenomena occurring within the phospholipid films. Specifically, we have observed distinguishable responses of the liquid crystal to exposure of the phospholipid-laden interface to phospholipase A2 (PLA2), bovine serum albumin (BSA), cytochrome-c, and lysozyme. These and other observations suggest that phospholipids self-assembled on liquid crystalline substrates may offer a generally useful approach to the amplification of interfacial phenomena occurring within these types of biomimetic films. |
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“Smart” Polymers on Surfaces and Colloids
8:30 AM-11:40 AM, Wednesday, March 31, 2004 Marriott -- Grand Ballroom J, Oral
Division of Colloid and Surface Chemistry |