COLL 179 |
| James A. Schwarz and Bhushan B. Hole. Department of Chemical Engineering and Materials Science, Syracuse University, 220 Hinds Hall, Syracuse, NY 13244 |
| Many biomaterials are processed by exogenic procedures similar to those used during catalyst preparation For example, bone substitute materials can be made from bovine bone that is heat treated at elevated temperatures, resulting in what is designated as anorganic bone. Thermal processing of bovine bone to ensure sterility when used as a bone substitute material results in the loss of carbonate, increase in crystallinity and hydroxyl content, which results in changes in the mechanical strength, bioactivity and buffering capacity of bone mineral. We have quantified the changes that occur during thermal processing using TGA, FTIR, and XRD. The biocompatibility of anorganic bone can be greatly enhanced by exogenic surface modifications that restore the surface chemical properties initially present on the bone surface. We describe some of these procedures. We also report the active sites for the adsorption of a biologically active peptide sequence on the surface of an anorganic bone material through the use of FTIR and AFM. The implications surrounding the identification of these sites will be discussed in relation to designing improved bone composite cements and the attachment of antibodies to materials used as bone substitutes. |
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The Science and Engineering of Catalyst Preparation
2:00 PM-5:25 PM, Monday, March 29, 2004 Marriott -- Orange County 3, Oral
Division of Colloid and Surface Chemistry |