COLL 338 |
| Michele D. Pysher and Mark A Hayes. Department of Chemistry and Biochemistry, Arizona State University, P.O. Box 871604, Tempe, AZ 85287-1604 |
| One of the more exciting and interesting self-assembling nano-scale structures is the liposome. Liposomes have been utilized for drug delivery, mimicking biological cells and membranes, transfer of genetic material, cosmetic and food ingredients, and for developing 3-D structures in nanofluidic applications. We have shown that the electrophoretic mobilities of liposome populations are sensitive to their intrinsic properties such as bilayer rigidity, surface functionality, and a coupling of surface charge across the bilayer. In this project we are utilizing capillary electrophoresis to qualitatively and quantitatively study the effects of these properties and compare the observed behaviors to classical electrokinetic and colloidal theories. Based on comparisons made to the theoretical predictions, our results suggest that liposomal deformation and field-induced polarization may occur during electrophoresis and these mechanisms help to describe many of the observed behaviors. |
|
Bio-Colloids
2:00 PM-4:40 PM, Tuesday, March 30, 2004 Marriott -- Orange County 3, Oral
Division of Colloid and Surface Chemistry |