COLL 485 |
| Atsushi Harada, Department of Applied Materials Science, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, Osaka 599-8531, Japan and Kazunori Kataoka, Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. |
| Self-assemblies of block copolymers have been received considerable attentions from not only fundamental aspects but also applied fields. Polymeric micelles were one of most investigated self-assembly of block copolymers. We have investigated new type of polymeric micelles, polyion complex (PIC) micelles, which were formed from the mixture of charged block copolymers with oppositely-charged compounds driven through electrostatic interaction in aqueous medium. PIC micelles could incorporate charged enzyme, egg white lysozyme, in the core by using poly(ethylene glycol)-b-poly(aspartic acid) as a counter polymer. In the core of PIC micelles, a remarkable enhancement of enzymatic reactivity was induced through a drastic change in the binding specificity between lysozyme and substrate. Further, on-off switching of this enhanced effect was achieved through the destabilization of the core domain by applying a pulse electric field. These unique features of the PIC micelles are relevant for their use as smart nano-reactors in the diverse fields of medical and biological engineering. |
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Symposium in Memory of Arthur W. Adamson
8:30 AM-11:50 AM, Thursday, April 1, 2004 Marriott -- Orange County 4, Oral
Division of Colloid and Surface Chemistry |
