COLL 235 |
| P. Sidney Sit, Durgadas Bolikal, Jonathan H. Melman, Matthew D Treiser, and Joachim Kohn. Department of Chemistry and Chemical Biology and New Jersey Center for Biomaterials, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854 |
| A new silanated tetraethylene glycol (STEG) was proposed and synthesized, which offers the readiness to modify silicon or silica surfaces. Under moisture-free conditions, an undecenyl moiety was first added to a monomethoxy-terminated tetraethyl glycol, followed by the addition of dichloromethylsilane to the C=C double bond. Modification of glass surfaces by STEG was confirmed by ellipsometry and X-ray photoelectron spectroscopy. Also, the surface properties of the glass surface changes from hydrophilicity to hydrophobicity. The silane layer was found to be stable under aqueous conditions. Using immunofluorescence assay, the relative adsorbed amount of fibrinogen and fibronectin on modified surfaces was reduced by about four-fold as compared to non-modified ones. Cell adhesion and morphology studies using rat lung fibroblasts do not show significant changes on both modified and non-modified glass surfaces. The potential of the newly synthesized STEG for biotechnological applications is discussed. |
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Posters: Fundamental Research in Surface and Colloid Chemistry
6:00 PM-8:00 PM, Monday, March 29, 2004 Disneyland -- North Exhibit Hall, Poster
Division of Colloid and Surface Chemistry |